Even those of you who have been living under a rock for a while, chances are you've still come across the two most popular cannabinoids found inside cannabis… THC and CBD, or their longer names Tetrahydrocannabinol and Cannabidiol. Lesser-known, however, is the other hundreds of cannabinoids inside the cannabis plant, most of which have not been studied in depth. We have compiled a summary of a handful of some you may not have heard much about… Yet!
Cannabigerol, or CBG, is known to treat digestive issues, glaucoma, cancer, skin conditions, and it acts as an antiseptic and neuroprotectant. CBG is a precursor to THC and converts into THC as the cannabis plant matures.
As a result, there is often a lower amount in most strains. CBG can usually be found in amounts of up to 1% of the plant. Despite this, however, without CBG, the cannabis plant would not be what it is today. It is known as the “mother cannabinoid” and is responsible for producing our THC and CBD molecules.
CBG has properties that can effectively be used for medical purposes. Growers and researchers are both working on finding ways to increase the amount found in individual plants.
CBDa or Cannabidiolic Acid main benefits can only be redeemed if you eat them raw. It converts to the more widely known cannabinoid CBD over time or if exposed to heat!
Benefits of CBDa are:
- Anti-proliferative (Anti-proliferative means it helps slow the spread of malignant cells in the body).
Although more research is needed, combined with the other anti-cancer properties of the other cannabinoids, the cannabis plant in its raw form, could be a powerful cancer-fighting substance.
Tetrahydrocannabivarin - If you can pronounce this correctly on your first try, you deserve an award! THCv is a chemical structure that is very similar to that of THC and helps amplify the effects of it.
Similar to the more well-known molecule THC, THCv has shown some fantastic benefits.
THCv is an anti-convulsant, neuroprotective, and more uniquely, it can even promote weight loss! One study showed the potential for THCv in reducing body fat and increasing energy levels. More research by GW pharmaceuticals showed promising evidence and the need to further explore THCv in treating Type 2 diabetes.
What makes this cannabinoid even more intriguing is the fact that it's only psychoactive depending on how high the dosage is. At lower dosages, this cannabinoid is non-psychoactive as it activates the CB1 receptor in the brain and acts as a CB1 antagonist. In higher dosages, it acts as a CB1 agonist and will make you feel "high".
CBDv, or Cannabidivarin, is a cannabinoid that has powerful anti-convulsant properties and is shown to suppress the expression of genes associated with epilepsy. In research conducted with mice, CBDv proved to be an effective anti-convulsant while having little to no effect on motor function. More research is needed to justify human trials, but it is extremely promising findings!
Similar to CBD, CBDv has also shown the ability to reduce nausea associated with several conditions as well as reducing pain and inflammation. What is clear is that more time and money needs to be spent in exploring this cannabinoid to increase the depth of knowledge and implications for human use.
One of the more recent discoveries is a cannabinoid called Cannabichromene, or CBC for short. Although most people have no idea that this cannabinoid exists, CBC is the third most prevalent cannabinoid found in cannabis. It can even rival the amount of CBD content in certain plants.
CBC does NOT get you “high” and is non-psychoactive. The receptors that it binds to in the brain are linked to pain perception – the Vanilloid Receptor 1 (TRPV) and the Transient Receptor Ankyrin 1 (TRPA1).
CBC has shown its capacity for some unique medical benefits:
- Encourages new brain cell growth (neurogenesis).
While these benefits can be found within the cannabinoid CBC, they can work even better when paired with THC. This effect is known as the entourage effect. Basically, this means that this particular cannabinoid is nowhere near as useful when it is isolated as it is when taken with its other cannabinoid friends. A bit like us humans!
CBN, or Cannabinol, is a metabolite of THC. Brought on by the oxidation of the plant’s chemicals, this means that it’s a by-product of THC through the aging process or when exposed to heat. In many cannabis plants, THC can go up to 30% or more. In comparison, CBN is rarely found to be more than 1%.
It has shown similar benefits to that of the other cannabinoids. Still, it's most notable characteristic is that it promotes bone growth. Although the research is very preliminary at the moment, CBN has also shown to act as a sedative and prolong sleep while also working as an analgesic (pain reliever). If you consume cannabis and then feel tired or sleepy, this has a lot to do with CBN.
If you want to speak to someone about the pathways available to you to access legal CBD in Australia, feel free to reach out to us via our contact form or call 1300 402 420, and a member of the team can discuss your options!